Inhibition of Tumor Cell Glycolysis
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چکیده
The discovery of the active group of the hydrogen-transferring enzymes — nicotinamide — for which O tto W a r b u r g was nominated by the Nobel Committee 1 “for a prize for the second time in 1944, when he again was found to deserve the honor”, has had a profound influence on all of biochemistry. The present paper describes a fundamental inhibition of intracellular tumor meta bolism produced by reduced diphosphopyridine nucleotide (DPNH2) added extracellularly.
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تاریخ انتشار 2013